Type 2 Diabetes Medications. Sulfonylureas Medications for Type 2 Diabetes Treatment

Sulfonylureas medications for Type 2 diabetes treatment were first type two medications marketed in 1957 for type 2 diabetes treatment. The first generation sulfonylureas which are tolinase, diabinese, and orinase, can improve hyperglycemia but potential drug interactions resulting in hypoglycemia make these type 2 diabetes medications less attractive than the following second generation of sulfonylureas drugs. Glipizide and glyburide drugs were introduced in 1984, with glimepiride followed in 1996.

How the sulfonylureas work? Sulfonylureas are type 2 diabetes medications known as “secretagogues” because their binding to beta-cell receptor results in an increase of insulin production and secretion. Once bound to the sulfonylurea receptor on the pancreatic beta-cell plasma membrane, the potassium channel closes. This reduces the exit of potassium from the beta cell, resulting in depolarization, allowing calcium influx through the plasma membrane. Increased levels of intracellular calcium result in prompt release of insulin into the plasma. All clear as day. Right? 🙂

Glimepiride as type 2 diabetes medication may havve a different mechanism of action than that of other sulfonylureas. Glimepiride used for type 2 diabetes treatment improves hyperglycemia by improving the efficiency of the intracellular glucose transporter protein known as GLUT4. Type 2 diabetes treatment with glimepiride may be insulin sparing. People taking Amaryl (glimepiride) type 2 diabetes medications have been shown to have lower fasting plasma insulin and C-peptide that do those taking Micronase type 2 diabetes medications or Diabeta pills (Micronase pills and Diabeta pills are other sulfonylureas drugs called glyburide; you can buy them online now). Glimepiride has been shonw to improve first- and second-phase insulin response. People using glimepiride (Amaryl 1mg pills) in their type 2 diabetes treatment tend to have much fewer incidents of hypoglycemia that people with type 2 diabetes using glibenclamide.

Sulfonylureas medications for type 2 diabetes treatment should be initiated at low doses (Amaryl 1mg pill once a day or Amaryl 2mg pill once a day) and increased weekly until target fasting blood glucose levels are less than 110 mg/dl which is normal blood glucose levels. For best effect, sulfonylureas type 2 diabetes medications should be given 1 hour before breakfast in order to improve first-phase insulin release from the pancreas or at bedtime to reduce overnight hepatic glucose production (production of glucose in the liver). The type 2 diabetes treatment with sulfonylureas medications generally results in a no more than 1 or 2 percent reduction in A1C levels. If person with type 2 diabetes has an A1C levels higher than 9 percent, it is strongly advised to switch to intensive diabetes management.

Sulfonylureas type 2 diabetes medications has few side effects. Weight gain is one of the possible side effects of sulfonylureas in type 2 diabetes treatment, which can be significant when used for people who already struggling with obesity. Hypoglycemia risk becomes a factor as person’s overall blood glucose control approaches normal blood glucose levels. Long-acting sulfonylureas such as chlorpropamide and glyburide (Diabeta pills and Micronase pills) are more likely to cause hypoglycemia.

You can order Amaryl 1 mg pills online now. Prescription drugs for type 2 diabetes treatment are also available online. There are many online pharmacies with diabetes medications.

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