Treatment of Diabetic Peripheral Neuropathic Pain with Tricyclic Antidepressants

Amitriptyline pills at dosages ranging from 25mg to 150 mg is the best studied tricyclic antidepressant in diabetic peripheral neuropathic pain. The tricyclic antidepressants are widely used to tret chronic pain syndromes including diabetic peripheral neuropathic pain. In high doses, antidepressants are most pronounced true antidepressant medications. But in lower doses, the antidepressants such as Amitriptyline and Desipramine have a more potent analgesic (painkiller) effect. Amitriptyline pills inhibit serotonin and norepinephrine reuptake in people with diabetic peripheral neuropathic pain. Curiously enough, none of the tricyclic antidepressants has been approved by the FDA for treatment of diabetic peripheral neuropathic pain despite their widespread use in diabetic pain management and treatment.


The most common side effects associated with use of tricyclic antidepressants include dry mouth, dizziness, blurred vision, constipation of course, fatigue, cardiac arrythmias, and urinary retention. People with autonomic dysfunction are not recommended to use tricyclic antidepressants such as Amitriptyline for treatment of diabetic peripheral neuropathic pain. Tricyclic antidepressants side effects will exacerbate autonomic dysfunction symptoms so better stay off it.

Desipramine is the other type of tricyclic antidepressants used for treatment of diabetic peripheral neuropathic pain same as Amitriptyline pills but Desipramine has lowest risk of side effects in tricyclic antidepressant drug class. Amitriptyline drug is most problematic with big list of side effects, although it is the most prescribed for the treatment of diabetic peripheral neuropathic pain, Desipramine pills and Amitriptyline pills you can order online now with prescription. You can buy Amitriptyline and Desipramine online now following my ads and use your prescription. Be careful, though, although the tricyclic antidepressants such as Desipramine and Amitriptyline are less costly and very helpful in the diabetic peripheral neuropathic pain treatment, high doses of these drugs can affect treatment adherence, increase drug-to-drug interactions, and increase side effects.

The primary objective of any treatment of diabetic peripheral neuropathic pain should be total elimination of pain. This goal is somewhat ambitious admittably, so any treatment should try to reduce the person’s initial presenting pain by half by using well researched means and medications combinations. For example, tricyclic antidepressants (TCAs) are should be avoided if person is over 60 years of age. Amitriptyline and Desipramine pills are not safe for use during pregnancy, efficacy of Desipramine or Amitriptyline pills in treatment of diabetic peripheral neuropathic pain in one patient can’t guaranty same levels of efficacy on another. None of tricyclic antidepressants (TCAs) to date reliably relieves all of pain for every person suffering from diabetic peripheral neuropathic pain (DPNP).

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