Signs and symptoms of diabetes are precursor to cardiovascular disease as a macrovascular diabetic complication. Diabetes mellitus disease is considered a cardiovascular risk-equivalent disease. The likelihood of dying of a first myocardial infraction is the same for people with signs and symptoms of diabetes disease as for a people without diabetes who has previously survived one myocardial infraction. Overwhelming majority of diabetes-related mortality is attributed to the three main forms of macrovascular diabetic complications. These three major macrovascular diabetic complications are: stroke, coronary heart disease, and peripheral vascular disease.