The neuropathies are among the most common of the long-term complications of diabetes disease, affecting up to 50 percent of all people with Type 1 diabetes or Type 2 diabetes mellitus. What is neuropathy? Neuropathy is a progressive loss of nerve fibers and nerve fibers density, resulting in altered nerve conduction velocity. Clinical features of neuropathies may vary greatly, from dermatology to podiatry, or from urology to cardiology. Diabetic neuropathy is the presence of symptoms or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes. Because up to 75 percent of people with diabetes may be asymptomatic, neuropathy cannot be diagnosed without an appropriate neurologic examination. All people with diabetes must be screened frequently to check for the presence of diabetic peripheral and autonomic neuropathy.