Risk of Cardiovascular Disease. Macrovascular Diabetic Complications
Signs and symptoms of diabetes are precursor to cardiovascular disease as a macrovascular diabetic complication. Diabetes mellitus disease is considered a cardiovascular risk-equivalent disease. The likelihood of dying of a first myocardial infraction is the same for people with signs and symptoms of diabetes disease as for a people without diabetes who has previously survived one myocardial infraction. Overwhelming majority of diabetes-related mortality is attributed to the three main forms of macrovascular diabetic complications. These three major macrovascular diabetic complications are: stroke, coronary heart disease, and peripheral vascular disease.
Individuals with type 1 diabetes symptoms have higher risk of mortality from cardiovascular disease if they have high blood pressure (hypertension), overt nephropathy, microalbuminuria, or autonomic cardiac neuropathy. People with type 1 diabetic symptoms also at much higher risk of cardiovascular disease if they smoking. Facts about diabetes: tobacco smoking and diabetes disease is a no-no combination! Age is also one of the risk factors of cardiovascular disease in people with type 1 diabetes symptoms.
Patients with type 2 diabetes symptoms are at great risk of cardiovascular diabetic complication in the presence of coronary artery disease. Type 2 diabetes symptoms together with hypertension (high blood pressure) is at risk of cardiovascular disease. Patients with signs and symptoms of diabetes are more prone to irreversible rather than reversible ischemic brain damage, and small lacunar infarcts are common. Stroke patients with signs and symptoms of diabetes have a higher death rate and poorer neurologic outcome with more severe disability.
People with signs and symptoms of diabetes have two to three times higher risk of cardiovascular disease, particularly the risk of atherothrombotic stroke, Prevalence of fatal and nonfatal coronary heart disease in patients with signs and symptoms of diabetes two to twenty times higher than for nondiabetic people of similar age without signs and symptoms of diabetes disease.
Facts about diabetes? Here they are. People showing signs and symptoms of diabetes are more likely to get acute myocardial infraction and such complications as arrythmias, heart failure, and death.
Risk of cardiovascular disease and endothelial dysfunction appear to be high in people with signs and symptoms of diabetes due to the multiple metabolic anomalies associated with high glucose levels. Damaged endothelial cells produce lower levels of nitric oxide, thereby complicating vasodilation. Inflammation within the endovascular environment is accelerated in the presence of high blood pressure and high blood glucose, dyslipidemia, tobacco cigarette smoking, and direct endothelial cell damage from cytokines such as TNF and C-reactive protein.
High blood glucose levels and high blood pressure are two major risk factors for development of cardiovascular disease in infividuals with signs and symptoms of diabetes.