Pramlintide (Symlin) for Type 1 Diabetes Treatment and Type 2 Diabetes Treatment

One of the most frustrating side effects associated with overall blood glucose control improvement in people with diabetes using intensive insulin therapy is weight gain. The addition of Symlin (pramlintide) to intensive insulin therapy for diabetes treatment improves long-term blood glucose control beyond that obtained with insulin therapy alone and significantly decreases weight gain and risk of hypoglycemia events. Pramlintide (Symlin) is an analogue to the native amylin.


Amylin is co-secreted from the pancreas with insulin in response to a glucose challenge. Once released, amylin reduces glucagon secretion, inhibits gastric emptying, and reduces food intake. A continuous amylin infusion results in weight loss by controlling satiety. Plasma levels of amylin in healthy individuals are lower in the fasting state and increase four times after a meal. People with Type one diabetes have amylin deficience along with insulin deficiency, but people with Type two diabetes often have amylin levels and insulin levels elevated.

Use of synthetic amylin (pramlintide) can improve blood glucose balance and reduce postprandial glucose spikes, while reducing A1C levels. In clinical trials, the addition of Symlin (pramlintide) to patients with Type 1 diabetes and Type 2 diabetes on intensive diabetes management has been shown to reduce the A1C levels approximately 1 percent from baseline compared with placebo. Three times more patients with diabetes on intensive diabetes management were able to achieve 7 percent target range of A1C levels when pramlintide (Symlin) was added to their insulin regimen.

Insulin is a natural growth hormone. Insulin injection doses are most of the time higher than the amount of insulin produced by normally functioning pancreas. Insulin injections may downregulate beta cell function to reduce their ability to produce and secrete amylin hormone. Amylin (pramlintide is a synthetic amylin) is a neuroendocrine hormone that binds to the area postrema of the brain and influence satiety. Addition of Symlin (pramlintide) injections for Type 1 diabetes treatment or Type two diabetes treatment mmay help lose weight. Patients with Type 1 diabetes with a body mass index (BMI) above 27 kg/m2 shown weight loss on average of 1.6 kg over a 26-weeks period compared with people with those patients with Type 1 diabetes taking placebo. It is even more striking for people with Type 2 diabetes disease. A 52-weeks study of patients with type 2 diabetes mellitus using twice daily Symlin (pramlintide) injections resulted in on average weigh loss of 1.5 kg compared with a 1 kg weigh gain for the placebo taking group.

Symlin (pramlintide) is very efficient addition to Type 1 diabetes treatment. Pramlintide (Symlin) is also helpful in weight loss. You can buy Symlin (pramlintide) online now with prescription. Please ask your doctor if pramlintide (Symlin) is good for your diabetes treatment plan and order Symlin online. You can find online pharmacy in your city to buy pramlintide.

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