Metformin and Type 2 Diabetes. Prescription Metformin for Diabetes Management
The best outcomes for Type 2 diabetes management have been noted when intensive diabetes treatment is initiated early in the course of the diabetes disease. But there are many other treatment options for Type 2 diabetes and one of those is sugar-lowering oral drugs. Metformin is one of those drugs taken to lower blood glucose levels.
Metformin is an excellent choice as the initial pharmacologic therapy for type 2 diabetes because of its effect on glycemia, absence of weight gain or induction of hypoglycemia.
Metformin has low cost and well accepted side effect profile. Metformin pills usually come in 500 mg, 850 mg, and 1000 mg doses. Metformin should be prescribed to the people with Type 2 diabetes together with lifestyle intervention at the time of diagnosis. Because Type 2 diabetes is a metabolic disorder in which the level of hyperglycemia mirrors the progressive failure of beta-cells function, changing of lifestyle fail to achieve and maintain targeted glycemic goals in most people with Type 2 diabetes. Hence Metformin is of great value and very beneficial at the time of diabetes diagnosis. All patients with symptomatic hyperglycemia and A1C level greater than 8.5 percent are urged to start intensive diabetes management. Metformin and other oral diabetes medications can lower A1C level for no more than 2 percent overall.
Metformin, a biguanide, is commonly referred to as “insulin sensitizer” bcause glucose levels improve without stimulation of insulin secretion. Metformin acts by decreasing hepatic glucose production, decreasing glucose absorption, and increasing glucose usage by muscles. As circulating glucose levels are being reduced, peripheral insulin resistance in the muscles and adipose tissue (fat tissue) may also improve. Metformin helps to improve glucose transport into muscle cells. Metformin as monotherapy has numerous beneficial effects on metabolic parameters and diabetes prevention.
People with impaired glucose tolerance (precursor to Type 2 diabetes) or impaired fasting glucose receiving metformin in 850 mg dose twice daily, had a 31 percent reduction in progression towards diabetes disease. Those people who were subject to lifestyle intervention, namely exercising 150 minutes per week and weight loss of 7 percent of baseline body weight, had a reduction in progression towards diabetes disease of 58 percent. Weight loss and exercise regimen work better but metformin works just fine for people with diabetes who are unable or unwilling to participate in lyfestyle-changing program. There are many people with Type 2 diabetes like this, lets not judge them.
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