Dipeptidyl Peptidase IV Inhibitor. Januvia Sitagliptin in Type 2 Diabetes Treatment
There is considerable interest in the dipeptidyl peptidase IV (DPP-IV) medications for type 2 diabetes treatment because, as a class, dipeptidyl peptidase IV drugs such as Januvia 25 mg pills (sitagliptin) appear to be well tolerated by people on type 2 diabetes treatment and can be used efficiently as monotherapy or as combination therapy together with Metformin (Glucophage, Fortamet, Glumetza drugs) oral diabetic medications. Beneficial effects of Januvia (sitagliptin) and dipeptidyl peptidase IV inhibitors as class on the pancreas beta-cell function raise the possibility that these sitagliptin agents of DPP-IV inhibitors may be able to modify the natural history of type 2 diabetes, given that Januvia used in proper type 2 diabetes treatment plan.
Dipeptidyl Peptidase IV inhibitors such as Januvia 50 mg pills available online are used to prevent rapid degradation of glucagon like peptide 1 hormone secreted from ileum and colon in response to a meal. Glucagon-like peptide-1 hormone is very beneficial in type 2 diabetes treatment because it helps to control blood sugar level in glucose-dependent fashion. But glucagon like peptide 1 hormone is rapidly degraded within 2 minutes of secretion by the enzyme dipeptidyl peptidase IV, or DPP-IV. One way to prolong the pharmacologic action of glucagon like peptide 1 produced inside the body of patient with type 2 diabetes symptoms, who are inherently glucagon-like peptide-1 deficient and has signs of high blood sugar, is to use Januvia (sitagliptin) 100 mg pills of other dipeptidyl peptidase IV inhibitor. Addition of Januvia (sitagliptin) to the type 2 diabetes treatment will help to control sugar level in blood. Januvia (sitagliptin) will inhibit DPP-IV enzymes in the person with type 2 diabetes symptoms so glucagon-like peptide-1 will not be degraded by DPP-IV enzymes. Januvia 100 mg pills as oral diabetic medication improve blood glucose levels control in type 2 diabetes treatment by preventing the rapid degradation of incretin mimetic hormones such as glucagon like peptide 1 and glucose dependent insulinotropic polypeptide, thereby improving postabsortive levels of GLP-1 and GIP in type 2 diabetes treatment.
Sitagliptin is the one of DPP-IV (dipeptidyl peptidase IV) inhibitors. Sitagliptin DPP-IV inhibitor is curently available on the market as Januvia pills. Buy Januvia pills online now with prescription for type 2 diabetes treatment. Find pharmacy online to buy Januvia (sitagliptin) pills to control sugar level in blood.
The effectiveness of Januvia (sitagliptin) as dipeptidyl peptidase IV inhibitor was examined in people with symptoms of type 2 diabetes as monotherapy and in combination therapy with metformin. More than 500 patients on type 2 diabetes treatment plan were given Januvia pills at a dose of 25 mg, 50 mg, or l00mg once daily in a 12-week placebo controlled study. No other oral diabetic medications were given. In comparison to the placebo-treated groups of people on type 2 diabetes treatment plan, Januvia (sitagliptin) therapy led to a significant reduction in A1C levels. Especially good results for A1C levels reduction were in those men and women with type 2 diabetes recieving Januvia 100 mg once daily. In placebo-treated group of patients with Type two diabetes, fasting plasma glucose increased by 0.2 mg/dl, whereas in a groups of patients with type two diabetes treated with Januvia (sitagliptin) A1C levels decreased by 10.7 mg/dl to 17 mg/dl in a dose pedendent manner. But no significant weight loss was observed with administration of Januvia (sitagliptin) drug. Exenatide as synthetic form of glucagon-like peptide-1 is much better for weight loss in patients on type 2 diabetes treatment regimen. Nonetheless, Januvia pills are very good for type 2 diabetes treatmment and we know where to buy Januvia cheap. Buy generic Januvia online now with prescription.